His bark is worse than his bite: perceptions and rationalization of canine aggressive behavior

Qualitative methods are increasingly used to investigate the complexities of the dog-human relationship. In order to inform a larger study of human dog interaction, a focus group study was carried out to address the question ‘How is aggressive behavior in dogs perceived and rationalized by people who have experience of dog behavior?’ Six focus groups, including three ‘non-professional’ groups (two groups of dog owners and one group of amateur trainers) and three ‘professional’ groups (a behaviorist group, veterinary group and academic group) were carried out, involving participants who were recruited opportunistically. The focus group transcripts were analyzed using thematic analysis. Findings indicated that participants who do not work with dogs in a professional capacity are largely defensive of dogs when discussing aggressive behavior. However, these participants also discussed factors that make a dog ‘risky’ and how responsible owners manage that risk and the characteristics of ‘dangerous dogs’. For the professional groups, aggressive behavior in dogs presents a barrier to everyday work. They considered working with the owners of dogs showing aggressive behavior and battling anthropogenic stereotypes and misconceptions to be part of the professional challenge. Professionals also contributed views on the nature of ‘dangerous dogs’ and demonstrated awareness of how perceptions could be distorted by the media and propagation of stereotypes. This research highlights the variability of perceptions about canine aggressive behavior. Findings can inform the critical interpretation of quantitative results, and offer a foundation for quantitative study of human directed aggressive behavior in dogs

Reducing the health risks of severe winter weather among older people in the United Kingdom: an evidence-based intervention

Excess winter morbidity and mortality among older people remain significant public health issues in those European countries which experience relatively mild winter temperatures, particularly the United Kingdom (UK), Ireland, Portugal and Spain. In the UK, episodes of severe winter weather, when ambient temperatures fall below 5x C, are associated with peaks in general practitioner consultations,hospital admissions, and cardiovascular deaths among those aged over 65. While research indicates that such health risks could be substantially reduced by the adoption of appropriate behavioural strategies, accessible and credible advice on how older people can reduce risk during ‘cold snaps’ is lacking. This paper describes a programme of research that aimed: (a) to translate the relevant scientific literature into practical advice for older people in order to reduce health risk during episodes of severe winter weather ; and (b) to integrate this advice with a severe winter weather ‘Early Warning System’ developed by the UK Met Office. An advice booklet was generated through a sequential process of systematic review, consensus development, and focus group discussions with older people. In a subsequent field trial, a combination of the Met Office ‘Early Warning System’ and the advice booklet produced behavioural change among older people consistent with risk reduction. The results also show that long-held convictions about ‘healthy environments ’ and anxieties about fuel costs are barriers to risk reduction

P.S. I love you : understanding the impact of posthumous digital messages

A number of digital platforms and services have recently emerged that allow users to create posthumous forms of communication, effectively arranging for the delivery of messages from ‘beyond the grave’. Despite some evidence of interest and popularity of these services, little is known about how posthumous messages may impact the people who receive them. We present a qualitative study that explores the type of experiences potentially triggered upon receiving such messages. Our findings firstly suggest that posthumous messaging services have the potential to alter the relationship between the bereaved and the deceased, and secondly provide insight into how users make sense of this altered relationship. Through the inference of a set of design considerations for posthumous communication services, we reveal a number of conflicts that are not easily solvable through technological means alone, and which may serve as starting points for further research. Our work extends the growing body of research that is concerned with digital interactions related to death and dying

Caregiving Dads, Breadwinning Mums: Pathways to the Division of Family Roles Among Role-Reversed and Traditional Parents

This study aimed to explore the circumstances and considerations that lead to the allocation of family roles among male carer/female breadwinner families in comparison to traditional parents. A sample of 236 parents with children from birth to 5 years old completed extensive questionnaires about their daily routines and perceptions of their division of responsibilities. Economic considerations or labor market constraints were mentioned as main reasons by parents in both traditional and role-reversed arrangements, however, parents in traditional roles were more likely to mention suitability for the role as a key consideration. The results further showed that main caregivers—fathers and mothers alike—had a higher perception of choice over the allocation of roles and were significantly more satisfied with their division than main breadwinners. The majority of breadwinners wished they could work fewer hours, and breadwinning mothers, more than fathers, wished their partner could work more hours. The findings also shed light on the relationship between perception of choice, satisfaction with the current arrangement and preference for a change in the future

Insiders, Outsiders, and the Struggle for Consecration in Cultural Fields: A Core-Periphery Perspective

Building on recent research emphasizing how legitimacy depends on consensus among audiences about candidates’ characteristics and activities, we examine the relationship between cultural producers’ (candidates) position in the social structure and the consecration of their creative work by relevant audiences. We argue that the outcome of this process of evaluation in any cultural field, whether in art or science, is a function of (1) candidates’ embeddedness within the field, and (2) the type of audience—that is, peers versus critics—evaluating candidates’ work. Specifically, we hypothesize that peers are more likely to favor candidates who are highly embedded in the field, whereas critics will not show such favoritism. We find support for these hypotheses in the context of the Hollywood motion picture industry

Boron-doped diamond dual-plate deep-microtrench device for generator-collector sulfide sensing

International audienceA BDD-BDD dual-plate microtrench electrode with 6 μm inter-electrode spacing is investigated using generator-collector electrochemistry and shown to give microtrench depth-dependent sulfide detection down to the μM levels. The effect of the microtrench depth is compared for a “shallow” 44 μm and a “deep” 180 μm microtrench and linked to the reduction of oxygen to hydrogen peroxide which interferes with sulfide redox cycling. With a deeper microtrench and a fixed collector potential at −1.4 V vs. SCE, two distinct redox cycling potential domains are observed at 0.0 V vs. SCE (2-electron) and at 1.1 V vs. SCE (6-electron)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Emotion and Crime: a mixed methods study

Crime and anti-social behaviour are issues of ongoing public concern. Surveys suggest that around 20 per cent of the population are ‘very worried’ about burglary and street crime, and that some groups (women, older people and ethnic minorities) are more fearful than others. Psychology has contributed little to this research even though emotion is one of its central concerns, and very few studies involve ‘qualitative’ analysis of what people themselves actually say about these issues. This social psychological research will study the talk of a community group who meet in a deprived inner-city area. The group are volunteers trying to improve community safety and quality of life, so crime and anti-social behaviour are frequently relevant to their work. Our data is gathered from recordings of their meetings, so it will show how they spontaneously speak and feel about these issues. Our analyses will identify the group’s shared understandings of crime and anti-social behaviour, and will show what their typical emotional responses to these issues are. More detailed knowledge of these emotional responses could be useful to government departments, community groups and local authorities, as well as to researchers, in understanding how best to tackle problems and meet people's concerns